On 11 January 1922, First use of insulin to treat diabetes in a human patient.
On 11 January 1922, Leonard Thompson, a 14-year-old boy with diabetes, who lay dying at the Toronto General Hospital, was given the first injection of insulin. However, the extract was so impure that Thompson suffered a severe allergic reaction, and further injections were cancelled.
Over the next 12 days, James Collip worked day and night to
improve the ox-pancreas extract, and a second dose was injected on the 23
January. This was completely successful, not only in having no obvious
side-effects, but in completely eliminating the glycosuria sign of diabetes.